With NSE, which will come as an upgrade at some point in mainnet (SDR will still be supported), PC1 will also run on GPUs, so it may be a good idea to design hybrid PC1/2 machines, so you'll have the option to upgrade (NSE should be a fair bit cheaper per byte than SDR)

Magik6k 4 hours ago
Separate C2 is probably a good idea (difference being less local storage / network bandwidth)